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KMID : 1007520220310101315
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Food Science and Biotechnology
2022 Volume.31 No. 10 p.1315 ~ p.1323
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Amelioration of radiation-induced liver damage by p-coumaric acid in mice
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Li Yun-Hong
Wu Jiang-Xue
He Qian
Gu Jia
Zhang Lin
Niu Hao-Zhi
Zhang Xin-Wen
Zhao Han-Ting
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Abstract
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Radiation-induced liver damage (RILD) is a spiny problem in radiotherapy or other circumstances that exposure to radiation. The need for radioprotective agent is increasing to protect liver tissue. This study aimed to explore the hepatoprotective effect of p-coumaric acid (CA) against RILD. C57BL/6 male mice were exposed to 4 Gy irradiation and administrated with CA for 4 days starting on the same day of irradiation. Mice were sacrificed to obtain blood and liver tissues on day 3.5 or 14 post irradiation, respectively. The blood and liver tissues were collected. As compared with the only irradiated group, CA supplementation improved liver morphology, decreased serum alanine aminotransferase and aspartate aminotransferase, inhibited BCL2-associated X (BAX) protein expression, and improved the mice hematopoietic function. CA at the dose of 100 mg/kg body weight showed better effect compared to the other doses. Thus, CA might possess potential to protect against RILD.
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KEYWORD
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p-coumaric acid, Radiation, Liver damage, Protective effect
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